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KMID : 1150820230360010001
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Anatomy & Biological Anthropology
2023 Volume.36 No. 1 p.1 ~ p.7
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Response of Renal Intercalated Cells to Dietary Potassium Intake
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Lee Su-Youn
Han Ki-Hwan
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Abstract
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While ancient humans consumed enough potassium (K+), modern humans have insufficient K+ intake. The renal collecting duct plays an important role in regulating K+ homeostasis. There are at least three different types of cells in the collecting duct. The purpose of this study is to examine the effects of dietary K+ intake on collecting duct intercalated cells. C57BL/6 mice had free access to a control (1%), low (<0.01%), or high (5%) K+ diet for 1 week. Kidney tissue were processed for light microscopic immunohistochemistry and image analysis. Excessive dietary K+ intake or deficiency significantly changed blood K+ concentrations in mice. The size of type A intercalated cells increased by about 1.6 times in the low K+ group and decreased in the high K+ group. Conversely, the size of type B intercalated cells decreased in the low K+ group and increased in the high K+ group. The response of NANB cells to dietary K+ intake was generally like type B cells. These results demonstrated that renal intercalated cells vary greatly with dietary K+ intake. The structural changes in response to K+ imbalance may be closely related to cardiovascular and renal disorders in modern humans.
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KEYWORD
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Kidney, Collecting duct, Potassium, Modern human
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